351) Yokozawa T., Kim H.J., Cho E.J.: Gravinol Ameliorates High-Fructose-Induced Metabolic Syndrome through Regulation of Lipid Metabolism and Proinflammatory State in Rats. J. Agric. Food Chem., 56, 5026-5032 (2008).
352) Kim J.Y., Kim H.S., Kang H.S., Choi J.S., Yokozawa T., Chung H.Y.: Antioxidant Potential of Dimethyl Lithospermate Isolated from Salvia miltiorrhiza (Red Sage) Against Peroxynitrite. J. Med. Food, 11, 21-28 (2008).
353) Lee Y.A, Cho E.J., Yokozawa T.: Protective Effect of Persimmon (Diospyros Kaki) Peel Proanthocyanidin against Oxidative Damage under H2O2-Induced Cellular Senescence. Biol. Pharm. Bull., 31, 1265-1269 (2008).
354) Lee Y.A, Cho E.J., Yokozawa T.: Effects of Proanthocyanidin Preparations on Hyperlipidemia and Other Biomarkers in Mouse Model of Type 2 Diabetes. J. Agric. Food Chem., 56, 7781-7789 (2008).
355) Kim Y.J., Kang K.S., Yokozawa T.: The anti-melanogenic effect of pycnogenol by its anti-oxidative actions. Food Chem. Toxicol., 46, 2466-2471 (2008).
356) Rhyu D.Y., Kang K.S., Sekiya M., Tanaka T., Park J.C., Yokozawa T.: Active Compounds Isolated from Traditional Chinese Prescription Wen-Pi-Tang Protecting Against Peroxynitrite-Induced LLC-PK1 Cell Damage. Am. J. Chin. Med., 36, 761-770 (2008).
357) Lee Y.J., Kim H.Y., Kang K.S., Lee J.G., Yokozawa T., Park J.H.: The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing. Bioorg. Med. Chem. Lett., 15, 4515-4520 (2008).
358) Cho E.J., Okamoto T., Yokozawa T.: Therapeutic efficacy of Kangen-karyu against H2O2-induced premature senescence. J. Pharm. Pharmacol., 60, 1537-1544 (2008).
359) Yokozawa T., Yamabe N., Kim H.Y., Kang K.S., Hur J.M., Park C.H., Tanaka T.: Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats. Biol. Pharm. Bull., 31, 1422-1428 (2008).
360) Kim H.Y., Kang K.S., Yamabe N., Yokozawa T.: Comparison of the Effects of Korean Ginseng and Heat-Processed Korean Ginseng on Diabetic Oxidative Stress. Am. J. Chin. Med., 36, 989-1004 (2008).
361) Zou Y., Kim D.H., Jung K.J., Heo H.S., Kim C.H., Baik H.S., Yu B.P., Yokozawa T., Chung H.Y.: Lysophosphatidylcholine Enhances Oxidative Stress Via the 5-Lipoxygenase Pathway in Rat Aorta During Aging. Rejuvenation Res., 12, 15-24 (2009).
362) Sekiya M., Ichiyanagi T., Ikeshiro Y., Yokozawa T.: The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in Amyotrophic Lateral Sclerosis Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord. Biol. Pharm. Bull., 32, 382-388 (2009).
363) Kang K.S., Tanaka T., Cho E.J., Yokozawa T.: Evaluation of the Peroxynitrite Scavenging Activity of Heat-Processed Ginseng. J. Med. Food, 12, 124-130 (2009).
364) Pu F., Motohashi K., Kaneko T., Tanaka Y., Manome N., Irie K., Takata J., Egashira N., Oishi R., Okamoto T., Sei Y., Yokozawa T., Mishima K., Iwasaki K., Fujiwara M.: Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats. J. Pharmacol. Sci., 109, 424-430 (2009).
365) Yamabe N., Kang K.S., Park C.H., Tanaka T., Yokozawa T.: 7-O-Galloyl-D-sedoheptulose Is a Novel Therapeutic Agent against Oxidative Stress and Advanced Glycation Endproducts in the Diabetic Kidney. Biol. Pharm. Bull., 32, 657-664 (2009).
366) Jang M.H., Kim H.Y., Kang K.S., Yokozawa T., Park J.H.: Hydroxyl Radical Scavenging Activities of Isoquinoline Alkaloids Isolated from Coptis chinensis. Arch. Pharm. Res., 32, 341-345 (2009).
367) Chung S.W., Kim M.K., Chung J.H., Kim D.H., Choi J.S., Anton S., Seo A.Y., Park K.Y., Yokozawa T., Rhee S.H., Yu B.P., Chung H.Y.: Peroxisome Proliferator-Activated Receptor Activation by a Short-Term Feeding of Zingerone in Aged Rats. J. Med. Food, 12, 345-350 (2009).
368) Yokozawa T., Park C.H., Noh J.S., Tanaka T., Cho E.J.: Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent. J. Pharm. Pharmacol., 61, 653-661 (2009).
369) Kim Y.J., Yokozawa T.: Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins. Biol. Pharm. Bull., 32, 1155-1159 (2009).
370) Ienaga K., Mikami H., Yokozawa T.: First Indications Demonstrating the Preventive Effects of NZ-419, a Novel Intrinsic Antioxidant, on the Initiation and/or Progression of Chronic Renal Failure in Rats. Biol. Pharm. Bull., 32, 1204-1208 (2009).
371) Kim H.Y., Okamoto T., Yokozawa T.: Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J. Ethnopharmacol., 124, 263-269 (2009).
372) Lee E.K., Chung S.W., Kim J.Y., Kim J.M., Heo H.S., Lim H.A., Kim M.K., Anton S., Yokozawa T., Chung H.Y.: Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-κB Signaling in C57/BL6 Mouse Kidney. J. Med. Food, 12, 542-551 (2009).
373) Yamabe N., Kang K.S., Hur J.M., Yokozawa T.: Matcha, a Powdered Green Tea, Ameliorates the Progression of Renal and Hepatic Damage in Type 2 Diabetic OLETF Rats. J. Med. Food, 12, 714-721 (2009).
374) Jung H.A., Min B.S., Yokozawa T., Lee J.H., Kim Y.S., Choi J.S.: Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids. Biol. Pharm. Bull., 32, 1433-1438 (2009).
375) Park C.H., Yamabe N., Noh J.S., Kang K.S., Tanaka T., Yokozawa T.: The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of db/db Mice. Biol. Pharm. Bull., 32, 1734-1740 (2009).
376) Park C.H., Cho E.J., Yokozawa T.: Protection Against Hypercholesterolemia by Corni Fructus Extract and Its Related Protective Mechanism. J. Med. Food, 12, 973-981 (2009).
377) Kim Y.J., Kim Y.A., Yokozawa T.: Protection against Oxidative Stress, Inflammation, and Apoptosis of High-Glucose-Exposed Proximal Tubular Epithelial Cells by Astaxanthin. J. Agric. Food Chem., 57, 8793-8797 (2009).
378) Yokozawa T., Lee Y.A, Zhao Q., Matsumoto K., Cho E.J.: Persimmon Oligomeric Proanthocyanidins Extend Life Span of Senescence-Accelerated Mice. J. Med. Food, 12, 1199-1205 (2009).
379) Lee Y.A, Cho E.J., Yokozawa T.: Oligomeric proanthocyanidins improve memory and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8. Br. J. Nutr., 103, 479-489 (2010).
380) Kim H.Y., Okubo T., Juneja L.R., Yokozawa T.: The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model. Br. J. Nutr., 103, 502-512 (2010).
381) Jung H.A., Yokozawa T., Kim B.W., Jung J.H., Choi J.S.: Selective Inhibition of Prenylated Flavonoids from Sophora flavescens against BACE1 and Cholinesterases. Am. J. Chin. Med., 38, 415-429 (2010).
382) Park C.H., Noh J.S., Tanaka T., Yokozawa T.: Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice. J. Pharm. Pharmacol., 62, 374-380 (2010).
383) Choi M.J., Kim B.K., Park K.Y., Yokozawa T., Song Y.O., Cho E.J.: Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System. Biol. Pharm. Bull., 33, 421-426 (2010).
384) Kim J.M., Lee E.K., Park G., Kim M.K., Yokozawa T., Yu B.P., Chung H.Y.: Morin modulates the oxidative stress-induced NF-κB pathway through its anti-oxidant activity. Free Radic. Res., 44, 454-461 (2010).
385) Kim Y.J., Kim Y.A., Yokozawa T.: Attenuation of oxidative stress and inflammation by gravinol in high glucose-exposed renal tubular epithelial cells. Toxicology, 270, 106-111 (2010).
386) Ienaga K., Yokozawa T.: Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a Novel Intrinsic Antioxidant, against the Progression of Chronic Kidney Disease at Stages 3 and 4 in Rats. Biol. Pharm. Bull., 33, 809-815 (2010).
387) Park C.H., Noh J.S., Yamabe N., Kang K.S., Tanaka T., Yokozawa T.: Beneficial effect of 7-O-galloyl-D-sedoheptulose on oxidative stress and hepatic and renal changes in type 2 diabetic db/db mice. Eur. J. Pharmacol., 640, 233-242 (2010).
388) Kim M.K., Chung S.W., Kim D.H., Kim J.M., Lee E.K., Kim J.Y., Ha Y.M., Kim Y.H., No J.K., Chung H.S., Park K.Y., Rhee S.H., Choi J.S., Yu B.P., Yokozawa T., Kim Y.J., Chung H.Y.: Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway. Exp. Gerontol., 45, 419-426 (2010).
389) Kang K.S., Yamabe N., Kim H.Y., Park J.H., Yokozawa T.: Effects of Heat-Processed Ginseng and Its Active Component Ginsenoside 20(S)-Rg3 on the Progression of Renal Damage and Dysfunction in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats. Biol. Pharm. Bull., 33, 1077-1081 (2010).
390) Yamabe N., Kim H.Y., Kang K.S., Zhao Q., Matsumoto K., Yokozawa T.: Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice. J. Ethnopharmacol., 129, 299-305 (2010).
391) Zhao Q., Yokozawa T., Yamabe N., Tsuneyama K., Li X., Matsumoto K.: Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. J. Ethnopharmacol., 131, 377-385 (2010).
392) Park C.H., Noh J.S., Yamabe N., Okamoto T., Kang K.S., Zhao Q., Matsumoto K., Shibahara N., Yokozawa T.: Renoprotective effect of Kangen-karyu on the development of diabetic nephropathy in type 2 diabetic db/db mice. J. Trad. Med., 27, 192-203 (2010).
393) Noh J.S., Kim H.Y., Park C.H., Fujii H., Yokozawa T.: Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice. Br. J. Nutr., 104, 1120-1128 (2010).
394) Yamabe N., Noh J.S., Park C.H., Kang K.S., Shibahara N., Tanaka T., Yokozawa T.: Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice. Eur. J. Pharmacol., 648, 179-187 (2010).
395) Noh J.S., Park C.H., Kim H.Y., Zhao Q., Yamabe N., Matsumoto K., Yokozawa T.: Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J. Pharm. Pharmacol., 63, 111-119 (2011).
396) Kim H.Y., Lee J.M., Yokozawa T., Sakata K., Lee S.: Protective activity of flavonoid and flavonoid glycosides against glucose-mediated protein damage. Food Chem., 126, 892-895 (2011).
397) Park C.H., Noh J.S., Tanaka T., Uebaba K., Cho E.J., Yokozawa T.: The Effects of Corni Fructus Extract and Its Fractions Against α-Glucosidase Inhibitory Activities in vitro and Sucrose Tolerance in Normal Rats. Am. J. Chin. Med., 39, 367-380 (2011).
398) Park C.H., Yamabe N., Okamoto T., Toriizuka K., Yokozawa T.: Chinese Prescription Kangen-karyu Ameliorates the Development of Diabetic Hepatic Damages via Regulating Oxidative Stress and Inflammation in the Liver of db/db Mice. Biol. Pharm. Bull., 34, 383-388 (2011).
399) Yamabe N., Lee J.G., Lee Y.J., Park C.H., Kim H.Y., Park J.H., Yokozawa T., Kang K.S.: The Chemical and 1,1-Diphenyl-2-Picrylhydrazyl Radical Scavenging Activity Changes of Ginsenosides Rb1 and Rg1 by Maillard Reaction. J. Ginseng Res., 35, 60-68 (2011).
400) Noh J.S., Park C.H., Yokozawa T.: Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism. Br. J. Nutr., 106, 1013-1022 (2011).