401) Kim Y.J., Kim Y.A., Yokozawa T.: Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells. Food Chem. Toxicol., 49, 2196-2201 (2011).
402) Okamoto T., Park C.H., Noh J.S., Toriizuka K., Sei Y., Park J.C., Yokozawa T.: Hepato-/reno-protective activity of Chinese prescription Kangen-karyu through inhibition of AGE formation and fibrosis-related protein expression in type 2 diabetes. J. Pharm. Pharmacol., 63, 952-959 (2011).
403) Park C.H., Noh J.S., Kim J.H., Tanaka T., Zhao Q., Matsumoto K., Shibahara N., Yokozawa T.: Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Biol. Pharm. Bull., 34, 1559-1565 (2011).
404) Park C.H., Tanaka T., Kim J.H., Cho E.J., Park J.C., Shibahara N., Yokozawa T.: Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology, 290, 14-21 (2011).
405) Zhao Q., Yokozawa T., Tsuneyama K., Tanaka K., Miyata T., Shibahara N., Matsumoto K.: Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain. Chin. Med., 6:33 (on line), 1-18 (2011).
406) Zhao Q., Matsumoto K., Tsuneyama K., Tanaka K., Li F., Shibahara N., Miyata T., Yokozawa T.: Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice. J. Pharmacol. Sci., 117, 230-242 (2011).
407) Park C.H., Tanaka T., Cho E.J., Park J.C., Shibahara N., Yokozawa T.: Glycerol-Induced Renal Damage Improved by 7-O-Galloyl-D-sedoheptulose Treatment through Attenuating Oxidative Stress. Biol. Pharm. Bull., 35, 34-41 (2012).
408) Park C.H., Tanaka T., Kim H.Y., Park J.C., Yokozawa T.: Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging. Evid. Based Complement. Alternat. Med., 2012, Article ID 418953, 7 pages (2012).
409) Park C.H., Noh J.S., Okamoto T., Park J.C., Yokozawa T.: Evaluation of Effects of Chinese Prescription Kangen-karyu on Diabetes-Induced Alterations such as Oxidative Stress and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Evid. Based Complement. Alternat. Med., 2012, Article ID 143489, 12 pages (2012).
410) Noh J.S., Park C.H., Tanaka T., Yokozawa T.: 7-O-Galloyl-D-sedoheptulose Attenuates Oxidative Stress-Induced Diabetic Injury via Decreasing Expression of Nuclear Factor-κB- and Apoptosis-Related Protein in the Liver. Biol. Pharm. Bull., 35, 950-956 (2012).
411) Park C.H., Noh J.S., Tanaka T., Yokozawa T.: 7-O-Galloyl-D-sedoheptulose ameliorates renal damage triggered by reactive oxygen species-sensitive pathway of inflammation and apoptosis. J. Pharm. Pharmacol., 64, 1730-1740 (2012).
412) Zhao Q., Niu Y., Matsumoto K., Tsuneyama K., Tanaka K., Miyata T., Yokozawa T.: Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement. Altern. Med., 12, 188 (2012).
413) Park C.H., Lee S.L., Okamoto T., Tanaka T., Yokozawa T.: Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney. Evid. Based Complement. Alternat. Med., 2012, Article ID 587902, 15 pages (2012).
414) Ienaga K., Park C.H., Yokozawa T.: Protective effect of an intrinsic antioxidant, HMH (5-hydroxy-1-methylhydantoin; NZ-419), against cellular damage of kidney tubules. Exp. Toxic. Pathol., 65, 559-566 (2013).
415) Park C.H., Tanaka T., Yokozawa T.: Anti-diabetic Action of 7-O-Galloyl-D-sedoheptulose, a Polyphenol from Corni Fructus, through Ameliorating Inflammation and Inflammation-Related Oxidative Stress in the Pancreas of Type 2 Diabetics. Biol. Pharm. Bull., 36, 723-732 (2013).
416) Park C.H., Rhyu D.Y., Sharma B.R., Yokozawa T.: Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-D-sedoheptulose treatment in 3T3-L1 adipocytes. Biomed. Prevent. Nutr., 3, 319-324 (2013).
417) Park C.H., Tanaka T., Yokozawa T.: Evaluation of 7-O-galloyl-D-sedoheptulose, isolated from Corni Fructus, in the adipose tissue of type 2 diabetic db/db mice. Fitoterapia, 89, 131-142 (2013).
418) Park C.H., Lee S.L., Noh J.S., Yokozawa T.: Rokumi-jio-gan-containing prescriptions regulate oxidative stress through improving dyslipidemia in a subtotal nephrectomized rat model. J. Ethnopharmacol., 148, 449-458 (2013).
419) Yokozawa T., Satoh A., Kim Y.J.: Modulation of Oxidative Stress by Proanthocyanidin in H2O2-Exposed Human Diploid Fibroblast Cells. Biosci. Biotechnol. Biochem., 77, 2056-2060 (2013).
420) Park C.H., Kim D.H., Park M.H., Kim M.K., Kim N.D., Kim C.M., Tanaka T., Yokozawa T., Chung H.Y., Moon H.R.: Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix Improve Age-Related Oxidative Stress and Inflammatory Response through the PI3K/Akt or MAPK Pathways. Am. J. Chin. Med., 42, 987-1005 (2014).
421) Park C.H., Rhyu D.Y., Noh J.S., Park C.M., Yokozawa T.: Effectiveness of Chinese prescription Kangen-karyu for dyslipidemia, using 3T3-L1 adipocytes and type 2 diabetic mice. Drug Discov. Ther., 8, 121-131 (2014).
422) Sharma B.R., Kim M.S., Yokozawa T., Rhyu D.Y.: Anti-oxidant and anti-diabetic activities of Lespedeza cuneata water extract. J. Med. Plants Res., 8, 935-941 (2014).
423) Park C.H., Yokozawa T., Noh J.S.: Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product-Related Pathway in db/db Mice. J. Nutr., 144, 1150-1157 (2014).
424) Jung Y.R., Kim D.H., Kim S.R., An H.J., Lee E.K., Tanaka T., Kim N.D., Yokozawa T., Park J.N., Chung H.Y.: Anti-Wrinkle Effect of Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-κB Signaling. PLoS ONE, 9, e102689 (2014).
425) Choi Y.Y., Maeda T., Fujii H., Yokozawa T., Kim H.Y., Cho E.J., Shibamoto T.: Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model. Nutr. Res., 34, 595-603 (2014).
426) Sung B., Park S., Ha Y.M., Kim D.H., Park C.H., Jung K.J., Kim M.S., Kim Y.J., Kim M.K., Moon J.O., Yokozawa T., Kim N.D., Yu B.P., Chung H.Y.: Salicylideneamino-2-thiophenol modulates nuclear factor-κB through redox regulation during the aging process. Geriatr. Gerontol. Int., 15, 211-219 (2015).
427) Park C.H., Xu F.H., Roh S.S., Song Y.O., Uebaba K., Noh J.S., Yokozawa T.: Astaxanthin and Corni Fructus Protect Against Diabetes-Induced Oxidative Stress, Inflammation, and Advanced Glycation End Product in Livers of Streptozotocin-Induced Diabetic Rats. J. Med. Food., 18, 337-344 (2015).
428) Park M.H., Kim S.J., Jeong H.O., Moon K.M., Son S., Kim D.H., Kim H.R., Kim M.J., Yun H.Y., Chun P., Je N.K., Yokozawa T., Moon H.R., Chung H.Y.: Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch. Pharm. Res., 38, 505-511 (2015).
429) Ahn J.H., Choi J.W., Choi J.M., Maeda T., Fujii H., Yokozawa T., Cho E.J.: Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell. Nutr. Res. Pract., 9, 123-128 (2015).
430) Lee C.M., Jung H.A., Oh S.H., Park C.H., Tanaka T., Yokozawa T., Choi J.S.: Kinetic and molecular docking studies of loganin and 7-O-galloyl-D-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase. Arch. Pharm. Res., 38, 1090-1098 (2015).
431) Park C.H., Noh J.S., Tanaka T., Roh S.S., Lee J.C., Yokozawa T.: Polyphenol isolated from Corni Fructus, 7-O-galloyl-D-sedoheptulose, modulates advanced glycation endproduct-related pathway in type 2 diabetic db/db mice. Arch. Pharm. Res., 38, 1270-1280 (2015).
432) Shin Y.O., Park C.H., Lee G.H., Yokozawa T., Roh S.S., Rhee M.H.: Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evid. Based Complement. Alternat. Med., 2015, Article ID 456846, 12 pages (2015).
433) Jung Y.R., Lee E.K., Kim D.H., Park C.H., Park M.H., Jeong H.O., Yokozawa T., Tanaka T., Im D.S., Kim N.D., Yu B.P., Mo S.H., Chung H.Y.: Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza. J. Nat. Prod., 78, 2110-2115 (2015).
434) Park S.K., Seong R.K., Kim J.A., Son S.J., Kim Y., Yokozawa T., Shin O.S.: Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway. Nutr. Res. Pract., 10, 3-10 (2016).
435) Bak J., Je N.K., Chung H.Y., Yokozawa T., Yoon S., Moon J.O.: Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NF-Kappa B and MAPK Signaling Pathways. Oxid. Med. Cell. Longev., 2016, Article ID 3935841, 12 pages (2016).
436) Choi J.S., Bhakta H.K., Fujii H., Min B.S., Park C.H., Yokozawa T., Jung H.A.: Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease. Arch. Pharm. Res., 39, 409-420 (2016).
437) Roh S.S., Kwon OJ., Yang J.H., Kim Y.S., Lee S.H., Jin J.S., Jeon Y.D., Yokozawa T., Kim H.J.: Allium hookeri root protects oxidative stress-induced inflammatory responses and β-cell damage in pancreas of streptozotocin-induced diabetic rats. BMC Complement. Altern. Med., 16, 63 (2016).
438) Park C.H., Lee J.Y., Kim M.Y., Shin S.H., Roh S.S., Choi J.S., Chung H.Y., Song Y.O., Shin Y.S., Yokozawa T.: Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Food Funct., 7, 3056-3063 (2016).
439) Bhakta H.K., Park C.H., Yokozawa T., Min B.S., Jung H.A., Choi J.S.: Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Arch. Pharm. Res., 39, 794-805 (2016).
440) Park C.H., Shin S.H., Lee E.K., Kim D.H., Kim M.J., Roh S.S., Yokozawa T., Chung H.Y.: Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother. Res., 31, 721-728 (2017).
441) Choi R.J., Roy A., Jung H.J., Ali M.Y., Min B.S., Park C.H., Yokozawa T., Fan T.P., Choi J.S., Jung H.A.: BACE1 molecular docking and anti-Alzheimer’s disease activities of ginsenosides. J. Ethnopharmacol., 190, 219-230 (2016).
442) Bhakta H.K., Park C.H., Yokozawa T., Tanaka T., Jung H.A., Choi J.S.: Potential anti-cholinesterase and β-site amyloid precursor protein cleaving enzyme 1 inhibitory activities of cornuside and gallotannins from Cornus officinalis fruits. Arch. Pharm. Res., 40, 836-853 (2017).
443) Park C.H., Shin M.R.., An B.K., Joh H.W., Lee J.C., Roh S.S., Yokozawa T.: Heat-Processed Scutellariae Radix Protects Hepatic Inflammation through the Amelioration of Oxidative Stress in Lipopolysaccharide-Induced Mice. Am. J. Chin. Med., 45, 1233-1252 (2017).
444) Kim D.H., Paudel P., Yu T., Ngo T.M., Kim J.A., Jung H.A., Yokozawa T., Choi J.S.: Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem. Biol. Interact., 278, 65-73 (2017).
445) Bhakta H.K., Paudel P., Fujii H., Sato A., Park C.H., Yokozawa T., Jung H.A., Choi J.S.: Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B. Arch. Pharm. Res., 40, 1314-1327 (2017).